CJC‑1295 and ipamorelin are two peptide hormones that have gained popularity among bodybuilders,
athletes, and researchers for their potential to enhance growth hormone secretion and promote muscle
growth, fat loss, and recovery. While each compound can be effective on its
own, many users combine them into a "blend" or "stack" to achieve synergistic effects,
hoping to maximize benefits while minimizing side‑effects.
The following sections detail the mechanisms of action, common adverse reactions, dosing considerations, and practical tips for those considering this
blend.
CJC‑1295 and Ipamorelin
CJC‑1295 is a synthetic analogue of growth hormone‑releasing hormone (GHRH).
It stimulates the pituitary gland to release endogenous growth hormone (GH) in a pulsatile
fashion that mimics natural physiology. The original formulation contains a
hexapeptide that is rapidly cleared from circulation; therefore, newer versions incorporate
an albumin‑binding domain (often referred to as CJC‑1295 with DAC or CJC‑1295 w/ DAC).
This modification extends the peptide’s half‑life to approximately 8–10 days, allowing
for less frequent dosing while maintaining
steady GH levels. By increasing GH, CJC‑1295 indirectly raises insulin‑like
growth factor‑1 (IGF‑1) in the bloodstream,
which is a key driver of anabolic processes such as protein synthesis,
cell proliferation, and tissue repair.
Ipamorelin is a selective growth hormone secretagogue that mimics ghrelin by
binding to the growth hormone secretagogue receptor 2 (GHSR‑2).
Unlike other secretagogues, ipamorelin is highly specific for GH release and does not significantly stimulate prolactin or cortisol
secretion. Its short half‑life—around 30 minutes—requires multiple daily injections
if used alone. However, when paired with a longer‑acting peptide like CJC‑1295, ipamorelin can provide the initial surge of GH needed to
kickstart the anabolic cascade while the longer‑acting analogue maintains baseline hormone levels.
Jump to
Overview of the blend and its purpose
Mechanisms of action for each peptide
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